Strychnine Poisoning in Toads


This pharmacological laboratory procedure demonstrates the Central Nervous System excitatory effect of Strychnine in toads. A dose of Strychnine is injected into the ventral lymph node of the toad then the hyper-stimulation of the Strychnine dosage is observed.


Stychnine acts as a selective competitive antagonist to block the inhibitory effects of glycine at all glycine receptors. Strychnine is a powerful convulsant with a characteristic motor pattern. In most laboratory animals, this convulsion is charaterized by tonic extension of the body and all limbs.

Author(s): George KoffuorView Details of Author
Year: 2010
Keywords: Pharmacology, hyper-stimulation of strychnine, Toads
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Strychnine is the principal alkaloid in nux vomica, the seeds of a tree strychnos nux vomica native to india. In demonstrating the cns ecitatory effect of strychnine, a toad is used.




Student should observe the CNS hyper-stimulation of strychnine.


Lesson Content


Watch the laboratory procedure on the Strychnine Poisoning in Toads.

Strychnine Poisoning in Toads (video)






George Koffuor
Department of Pharmacology
College of Health Sciences, KNUST
Kumasi, Ghana

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KNUST, Kumasi - Ghana

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KNUST, Kumasi - Ghana

Voice Over
ella kasanga

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Kumasi, Ghana




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