Strychnine Poisoning in Toads

Overview

This pharmacological laboratory procedure demonstrates the Central Nervous System excitatory effect of Strychnine in toads. A dose of Strychnine is injected into the ventral lymph node of the toad then the hyper-stimulation of the Strychnine dosage is observed.

 

Stychnine acts as a selective competitive antagonist to block the inhibitory effects of glycine at all glycine receptors. Strychnine is a powerful convulsant with a characteristic motor pattern. In most laboratory animals, this convulsion is charaterized by tonic extension of the body and all limbs.

Author(s): George KoffuorView Details of Author
Year: 2010
Keywords: Pharmacology, hyper-stimulation of strychnine, Toads
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cc-by-nc© 2010, KNUST

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Any information and/or video demonstration in this material is intended to inform and to educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. You should speak to your lecturer, healthcare professional or lab technician and make an appointment, if you have questions or concerns about this information.

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Introduction

 

Strychnine is the principal alkaloid in nux vomica, the seeds of a tree strychnos nux vomica native to india. In demonstrating the cns ecitatory effect of strychnine, a toad is used.

 

Objectives

 

Student should observe the CNS hyper-stimulation of strychnine.

 

Lesson Content

 

Watch the laboratory procedure on the Strychnine Poisoning in Toads.

Strychnine Poisoning in Toads (video)

 

 

Credits

 

Author
gkoff

George Koffuor
Department of Pharmacology
College of Health Sciences, KNUST
Kumasi, Ghana

 
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Voice Over
ella kasanga

Ella Kasanga
Kumasi, Ghana

 

Acknowledgment

 

This programme was produced with support from the following:

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